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Article

Recruitment of multi-segment genomic RNAs by Bluetongue virus requires a preformed RNA network.

Nucleic acids research - 12 Aug 2024

Sung Po-Yu, Phelan Jody E, Luo Dongsheng, Kulasegaran-Shylini Raghavendran, Bohn Patrick, Smyth Redmond P, Roy Polly

Abstract excerpt

How do segmented RNA viruses correctly recruit their genome has yet to be clarified. Bluetongue virus is a double-stranded RNA virus with 10 segments of different sizes, but it assembles its genome in single-stranded form through a series of specific RNA-RNA interactions prior to packaging. In this study, we determined the structure of each BTV transcript, individually and in different combinations, using...

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Identifiers

PMID: 38769067
DOI: 10.1093/nar/gkae404
PMCID: PMC11317150

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