Article
Clinical and immunophenotype correlating with response to immunotherapy in paediatric patients with primary liver carcinoma. A case series.
EBioMedicine - 1 Jun 2024
O'Neill Allison F, Church Alanna J, Feraco Angela, Spidle Jennifer, Wall Catherine B, Kim Heung Bae, Elisofon Scott, Vakili Khashayar, Pimkin Max, Dharia Neekesh V, Shelman Nathan R, Perez-Atayde Antonio R, Rodriguez-Galindo Carlos
Abstract excerpt
BACKGROUND: Paediatric hepatocellular carcinomas (HCC) traditionally arise in the context of a normal structural and functional liver and carry a dismal prognosis. While chemotherapy is the frontline standard, there is emerging interest in the study of immunotherapies for paediatric patients with relapsed/refractory disease. There is limited data to support whether immunotherapies will be of utility in this...
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