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Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents

28 Apr 2024

Abstract excerpt

A series of flavanols were synthesized to assess their biological activity against human non-small cell lung cancer cells (A549). Among the sixteen synthesized compounds, it was observed that compounds 6k (3.14 ± 0.29 µM) and 6l (0.46 ± 0.02 µM) exhibited higher potency compared to 5-fluorouracil (5-Fu, 4.98 ± 0.41 µM), a clinical anticancer drug which was used as a positive control. Moreover, compound 6l...

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PMID: 38731532
DOI: 10.3390/molecules29092041

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