Article
Microsatellite Instability, Mismatch Repair, and Tumor Mutation Burden in Lung Cancer.
Surgical pathology clinics - 1 Jun 2024
Rosca Oana C, Vele Oana E
Abstract excerpt
Since US Food and Drug Administration approval of programmed death ligand 1 (PD-L1) as the first companion diagnostic for immune checkpoint inhibitors (ICIs) in non-small cell lung cancer, many patients have experienced increased overall survival. To improve selection of ICI responders versus nonresponders, microsatellite instability/mismatch repair deficiency (MSI/MMR) and tumor mutation burden (TMB) came into...
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