Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with Irritable Bowel Syndrome.

doi:10.3390/ijms25084293

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Article

Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with Irritable Bowel Syndrome.

International journal of molecular sciences - 12 Apr 2024

Chimienti Guglielmina, Russo Francesco, Bianco Antonella, Maqoud Fatima, De Virgilio Caterina, Galeano Grazia, Orlando Antonella, Riezzo Giuseppe, D'Attoma Benedetta, Ignazzi Antonia, Linsalata Michele, Prospero Laura, Franco Isabella, Bagnato Claudia Beatrice, Curci Ritanna, Coletta Sergio

Abstract excerpt

Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various approaches capable of managing the symptoms, physical activity is still under investigation. Despite its benefits, it promotes oxidative stress and inflammation. Mitochondria impacts gut disorders by releasing damage-associated molecular patterns, such as cell-free mtDNA (cf-mtDNA), which support inflammation. This study...

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PMID: 38673878
DOI: 10.3390/ijms25084293
PMCID: PMC11050617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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