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Article

Atrophic changes in thyroid tumors are strong indicators of underlying DICER1 mutations: a bi-institutional genotype-phenotype correlation study.

Virchows Archiv : an international journal of pathology - 1 Jul 2024

Condello Vincenzo, Roberts James W, Stenman Adam, Larsson Catharina, Viswanathan Kartik, Juhlin C Christofer

Abstract excerpt

Somatic and biallelic DICER1 mutations are reported in subsets of thyroid tumors, supporting the role of this gene in thyroid tumor development. As recent studies have brought attention to macrofollicular patterns, atrophic changes, and papillary structures as being associated with DICER1 mutations, we sought to explore these observations in a bi-institutional cohort. A total of 61 thyroid lesions (54 tumors and...

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Identifiers

PMID: 38637342
DOI: 10.1007/s00428-024-03802-y
PMCID: PMC11271315

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