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Article

Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.

PLoS pathogens - 1 Apr 2024

VanInsberghe David, McBride Dillon S, DaSilva Juliana, Stark Thomas J, Lau Max S Y, Shepard Samuel S, Barnes John R, Bowman Andrew S, Lowen Anice C, Koelle Katia

Abstract excerpt

Patterns of within-host influenza A virus (IAV) diversity and evolution have been described in natural human infections, but these patterns remain poorly characterized in non-human hosts. Elucidating these dynamics is important to better understand IAV biology and the evolutionary processes that govern spillover into humans. Here, we sampled an IAV outbreak in pigs during a week-long county fair to characterize...

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Identifiers

PMID: 38626244
DOI: 10.1371/journal.ppat.1012131
PMCID: PMC11051653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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