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Article

A stochastic programming approach to the antibiotics time machine problem.

Mathematical biosciences - 1 Jun 2024

Mesüm Oğuz, Atilgan Ali Rana, Kocuk Burak

Abstract excerpt

Antibiotics Time Machine is an important problem to understand antibiotic resistance and how it can be reversed. Mathematically, it can be modeled as follows: Consider a set of genotypes, each of which contain a set of mutated and unmutated genes. Suppose that a set of growth rate measurements of each genotype under a set of antibiotics is given. The transition probabilities of a 'realization' of a Markov chain...

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Identifiers

PMID: 38604597
DOI: 10.1016/j.mbs.2024.109191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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