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Article

Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses.

Journal of virology - 14 May 2024

Tang Xuechao, Li Sufen, Zhou Jinzhu, Bian Xianyu, Wang Jianxin, Han Nan, Zhu Xuejiao, Tao Ran, Wang Wei, Sun Min, Li Peng, Zhang Xuehan, Li Bin

Abstract excerpt

Porcine rotaviruses (PoRVs) cause severe economic losses in the swine industry. P[7] and P[23] are the predominant genotypes circulating on farms, but no vaccine is yet available. Here, we developed a bivalent subunit PoRV vaccine using truncated versions (VP4*) of the VP4 proteins from P[7] and P[23]. The vaccination of mice with the bivalent subunit vaccine elicited more robust neutralizing antibodies (NAbs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38591886
DOI: 10.1128/jvi.00212-24
PMCID: PMC11092341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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