Article
Early Immunomodulatory Program Triggered by Protolerogenic Bifidobacterium pseudolongum Drives Cardiac Transplant Outcomes.
Transplantation - 1 Jul 2024
Gavzy Samuel J, Kensiski Allison, Saxena Vikas, Lakhan Ram, Hittle Lauren, Wu Long, Iyyathurai Jegan, Dhakal Hima, Lee Zachariah L, Li Lushen, Lee Young S, Zhang Tianshu, Lwin Hnin Wai, Shirkey Marina W, Paluskievicz Christina M, Piao Wenji, Mongodin Emmanuel F, Ma Bing, Bromberg Jonathan S
Abstract excerpt
BACKGROUND: Despite ongoing improvements to regimens preventing allograft rejection, most cardiac and other organ grafts eventually succumb to chronic vasculopathy, interstitial fibrosis, or endothelial changes, and eventually graft failure. The events leading to chronic rejection are still poorly understood and the gut microbiota is a known driving force in immune dysfunction. We previously showed that gut...
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