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Ponalfil trial for adults with Philadelphia chromosome‐positive acute lymphoblastic leukemia: Long‐term results

1 Apr 2024

Abstract excerpt

The introduction of tyrosine kinase inhibitors (TKI) has significantly changed the outcome of children and adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).1 Several phase 2 trials have shown improved outcomes with the incorporation of ponatinib to first-line therapy, either in combination with chemotherapy or with blinatumomab,2-4 and a matching adjusted indirect comparison of...

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PMID: 38566805
DOI: 10.1002/hem3.67

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