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The new N2, N4-diphenylpyridine-2,4-diamine deuterated derivatives as EGFR inhibitors to overcome C797S-mediated resistance.

Bioorganic chemistry - 1 May 2024

Liu Jiadai, Nie Wenyan, Nie Haoran, Yao Han, Ren Yuanyuan, Cao Longcai, Qiu Jiaqi, Wang Mengxuan, Li Xingshu, An Baijiao, Jia Xian

Abstract excerpt

A series of new deuterated and non-deuterated N2, N4-diphenylpyridine - 2,4-diamine derivatives were synthesized and evaluated as EGFR C797S-mediated resistance inhibitors. Most of these compounds exhibited potent antiproliferative activity against Baf3-EGFR L858R/T790M/C797S and Baf3-EGFR Del19/T790M/C797S cancel cell lines, with IC50 values in the nanomolar concentration range. Among them, compound 14l...

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Identifiers

PMID: 38554675
DOI: 10.1016/j.bioorg.2024.107313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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