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Massive Parallel DNA Sequencing of Patients with Inherited Cardiomyopathies in Cyprus and Suggestion of Digenic or Oligogenic Inheritance.

Genes - 28 Feb 2024

Koutsofti Constantina, Ioannides Marios, Polydorou Christiana, Papagregoriou Gregory, Malatras Apostolos, Michael George, Hadjiioannou Irene, Pieri Stylianos, Loizidou Eleni M, Eftychiou Christos, Papasavvas Elias, Christophides Theodoros, Alkelai Anna, Kapoor Manav, Shuldiner Alan R, Avraamides Panayiotis, Deltas Constantinos

Abstract excerpt

Inherited cardiomyopathies represent a highly heterogeneous group of cardiac diseases. DNA variants in genes expressed in cardiomyocytes cause a diverse spectrum of cardiomyopathies, ultimately leading to heart failure, arrythmias, and sudden cardiac death. We applied massive parallel DNA sequencing using a 72-gene panel for studying inherited cardiomyopathies. We report on variants in 25 families, where...

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Cardiomyopathies
Cyprus
Multifactorial Inheritance
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

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PMID: 38540378
DOI: 10.3390/genes15030319
PMCID: PMC10970479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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