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Oral Microbiota and Porphyromonas gingivalis Kgp Genotypes Altered in Parkinson's Disease with Mild Cognitive Impairment.

Molecular neurobiology - 1 Nov 2024

Li Dongcheng, Ren Tengzhu, Li Hao, Huang Mingdi, Chen Jiaxin, He Qishan, Lv Wei, Liu Hailing, Xu Renshi, Zhang Xiong

Abstract excerpt

Cognitive impairment (CI) is a common complication of the non-motor symptoms in Parkinson's disease (PD), including PD with mild cognitive impairment (PD-MCI) and PD dementia. Recent studies reported the oral dysbiosis in PD and CI, respectively. Porphyromonas gingivalis (P. gingivalis), a pathogen of oral dysbiosis, plays an important role in PD, whose lysine-gingipain (Kgp) could lead to AD-type pathologies. No...

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PMID: 38536604
DOI: 10.1007/s12035-024-04119-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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