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Fenretinide in Young Women at Genetic or Familial Risk of Breast Cancer: A Placebo-Controlled Biomarker Trial.

Cancer prevention research (Philadelphia, Pa.) - 4 Jun 2024

Aristarco Valentina, Serrano Davide, Maisonneuve Patrick, Guerrieri-Gonzaga Aliana, Lazzeroni Matteo, Feroce Irene, Macis Debora, Cavadini Elena, Albertazzi Elena, Jemos Costantino, Omodeo Salè Emanuela, Cortesi Laura, Massarut Samuele, Gulisano Marcella, Daidone Maria Grazia, Johansson Harriet, Bonanni Bernardo

Abstract excerpt

Fenretinide, a retinoid with a low-toxicity profile that accumulates in the breast, has been shown to prevent second breast cancer in young women. Fenretinide exhibits apoptotic and antiinvasive properties and it improves insulin sensitivity in overweight premenopausal women with insulin resistance. This study aimed to further characterize its role in cancer prevention by measuring circulating biomarkers related...

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PMID: 38530139
DOI: 10.1158/1940-6207.CAPR-23-0422

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BRCA1
SHBG

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