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Article

TP63 truncating mutation causes increased cell apoptosis and premature ovarian insufficiency by enhanced transcriptional activation of CLCA2.

Journal of ovarian research - 25 Mar 2024

Fan Yali, Chen Shuya, Chu Chunfang, Yin Xiaodan, Jin Jing, Zhang Lingyan, Yan Huihui, Cao Zheng, Liu Ruixia, Xin Mingwei, Li Lin, Yin Chenghong

Abstract excerpt

BACKGROUND: Premature ovarian insufficiency (POI) is a severe disorder leading to female infertility. Genetic mutations are important factors causing POI. TP63-truncating mutation has been reported to cause POI by increasing germ cell apoptosis, however what factors mediate this apoptosis remains unclear. METHODS: Ninety-three patients with POI were recruited from Beijing Obstetrics and Gynecology Hospital,...

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Identifiers

PMID: 38528613
DOI: 10.1186/s13048-024-01396-2
PMCID: PMC10962206

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