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Article

Investigation of the rhythmic recruitment of tear neutrophils to the ocular surface and their phenotypes.

Scientific reports - 25 Mar 2024

Jin Yutong, Minten Ceili, Jenkins Mara, Jones Lyndon, Gorbet Maud

Abstract excerpt

Hundreds of thousands of polymorphonuclear neutrophils (PMNs) are collected from the ocular surface upon waking, while few are harvested during daytime. This study aimed to investigate potential factors contributing to the circadian infiltration of tear PMNs, including changes in IL-8 and C5a in tears, and their phenotypes across different time points in a 24-h cycle. Tear PMNs were collected using a gentle...

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Identifiers

PMID: 38528025
DOI: 10.1038/s41598-024-57311-8
PMCID: PMC10963749

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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