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Physiological basis for xenotransplantation from genetically modified pigs to humans

22 Mar 2024

Abstract excerpt

The collective efforts of scientists over multiple decades have led to advancements in molecular and cellular biology-based technologies including genetic engineering and animal cloning that are now being harnessed to enhance the suitability of pig organs for xenotransplantation into humans. Using organs sourced from pigs with multiple gene deletions and human transgene insertions, investigators have overcome...

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PMID: 38517040
DOI: 10.1152/physrev.00041.2023

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