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Article

Heterozygous Pyrin (MEFV) E148Q allele carriers indicate a reduced glaucoma risk for Turkish population: a prospective clinical analysis.

Ophthalmic genetics - 1 Aug 2024

Muhsinoglu Orkun, Akalin Ibrahim, Karadag Remzi, Yilmaz Sarenur, Bayramlar Huseyin, Nicholson James D

Abstract excerpt

PURPOSE: The MEFV gene encodes pyrin, a protein linked to increased severity of symptoms in Familial Mediterranean Fever (FMF). We consider that inflammation due to MEFV variants would increase eye inflammation and damage aqueous humor regulation. The present study is the first analysis investigating a MEFV (E148Q) variant as a marker protecting from glaucoma. METHODS: In this prospective clinical analyze, we...

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Source

Identifiers

PMID: 38482581
DOI: 10.1080/13816810.2024.2324362

Genes

MEFV

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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