Article
Diagnostic Imaging for Retinoblastoma Cancer Staging: Guide for Providing Essential Insights for Ophthalmologists and Oncologists.
Radiographics : a review publication of the Radiological Society of North America, Inc - 1 Apr 2024
Pai Vivek, Muthusami Prakash, Ertl-Wagner Birgit, Shroff Manohar M, Parra-Fariñas Carmen, Sainani Kanchan, Kletke Stephanie, Brundler Marie-Anne, Mallipatna Ashwin
Abstract excerpt
Retinoblastoma is the most common cause of all intraocular pediatric malignancies. It is caused by the loss of RB1 tumor suppressor gene function, although some tumors occur due to MYCN oncogene amplification with normal RB1 genes. Nearly half of all retinoblastomas occur due to a hereditary germline RB1 pathogenic variant, most of which manifest with bilateral tumors. This germline RB1 mutation also predisposes...
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