Article
Impact of carbamazepine on SMARCA4 (BRG1) expression in colorectal cancer: modulation by KRAS mutation status.
Investigational new drugs - 1 Apr 2024
Shaykevich Aaron, Chae Danbee, Silverman Isaac, Bassali Jeremy, Louloueian Netanel, Siegman Alexander, Bandyopadhyaya Gargi, Goel Sanjay, Maitra Radhashree
Abstract excerpt
SMARCA4 is a gene traditionally considered a tumor suppressor. Recent research has however found that SMARCA4 likely promotes cancer growth and is a good target for cancer treatment. The drug carbamazepine, an autophagy inducer, was used on colorectal cancer cell lines, HCT1116 and Hke3 (KRAS mutant and wildtype). Our study finds that Carbamazepine affects SMARCA4 levels and that this effect is different...
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