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Inter-phylum circulation of a beta-lactamase-encoding gene: a rare but observable event

5 Mar 2024

Abstract excerpt

ABSTRACT Beta-lactamase-mediated degradation of beta-lactams is the most common mechanism of beta-lactam resistance in Gram-negative bacteria. Beta-lactamase-encoding genes can be transferred between closely related bacteria, but spontaneous inter-phylum transfers (between distantly related bacteria) have never been reported. Here, we describe an extended-spectrum beta-lactamase (ESBL)-encoding gene ( bla MUN-1 )...

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PMID: 38441061
DOI: 10.1128/aac.01459-23

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