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Influential factors on urine EV DNA methylation detection and its diagnostic potential in prostate cancer

19 Feb 2024

Abstract excerpt

The value of Extracellular vesicles (EVs) diagnostic markers is widely recognized. However, current research on EV DNA remains limited. This study investigates the biological properties, preprocessing factors, and diagnostic potential of EV DNA. We found that DNA positive vesicles account for 23.3% ± 6.7% of the urine total EV, with a large amount of DNA attached to the outside. EV DNA fragments are large, there...

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PMID: 38440192
DOI: 10.3389/fgene.2024.1338468

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