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Limitations in harnessing oral RNA interference as an antiviral strategy in Aedes aegypti

16 Feb 2024

Abstract excerpt

Mosquitoes, particularly Aedes aegypti , are critical vectors for globally significant pathogenic viruses. This study examines the limitations of oral RNA interference (RNAi) as a strategy to disrupt viral transmission by Ae. aegypti . We hypothesized that double-stranded RNA (dsRNA) targeting the Zika virus (ZIKV) or chikungunya virus (CHIKV) genomes produced by engineered bacterial symbionts could trigger an...

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PMID: 38433898
DOI: 10.1016/j.isci.2024.109261

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