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A mutation in LPAR2 activates the miR-939-5p-LPAR2-PI3K/AKT axis to regulate the proliferation and apoptosis of granulosa cells in sheep.

Theriogenology - 15 Apr 2024

Zhang Runan, Liu Yufang, Li Wentao, Wang Peng, Liu Ziyi, Wen Yuliang, Chu Mingxing, Wang Linjie

Abstract excerpt

Lysophosphatidic acid receptor-2 (LPAR2) is a G protein-coupled receptor, which is involved in various physiological processes such as cell development, proliferation, and apoptosis, and is thought to play an important role in follicular development and reproduction. There is evidence that miRNA recognition elements (MRE) in the gene 3'UTR often contain single nucleotide polymorphisms (SNPs) that can alter the...

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PMID: 38368704
DOI: 10.1016/j.theriogenology.2024.02.010

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