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Article

Hemophore-like proteins of the HmuY family in the oral and gut microbiome: unraveling the mystery of their evolution

2 Feb 2024

Abstract excerpt

SUMMARY Heme (iron protoporphyrin IX, FePPIX) is the main source of iron and PPIX for host-associated pathogenic bacteria, including members of the Bacteroidota (formerly Bacteroidetes) phylum. Porphyromonas gingivalis , a keystone oral pathogen, uses a unique heme uptake (Hmu) system, comprising a hemophore-like protein, designated as the first member of the novel HmuY family. Compared to classical, secreted...

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PMID: 38305743
DOI: 10.1128/mmbr.00131-23

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