Article
A case report of a truncated ABL1 mutation in 2 cases with Philadelphia chromosome-positive B cell precursor acute lymphoblastic leukemia.
International journal of hematology - 1 Feb 2024
Kato Kana, Takagi Shinsuke, Takano Hirofumi, Tsunoda Shinichi, Watanabe Otoya, Yamaguchi Kyosuke, Kageyama Kosei, Kaji Daisuke, Taya Yuki, Nishida Aya, Ishiwata Kazuya, Yamamoto Hisashi, Yamamoto Go, Asano-Mori Yuki, Koike Yukako, Makino Shigeyoshi, Wake Atsushi, Taniguchi Shuichi, Uchida Naoyuki
Abstract excerpt
Acquired point mutations in the ABL1 gene are widely recognized as a cause of Philadelphia chromosome-positive B cell precursor acute lymphoblastic leukemia (Ph+ B-ALL) that is resistant to tyrosine kinase inhibitors, whereas there are few reports about other types of the ABL1 mutation. Here, we report 2 cases of Ph+ B-ALL gaining a partial deletion type mutation of the ABL1 gene (Δ184-274 mutation), which...
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