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Article

Role of Single-Nucleotide Polymorphisms in Genes Implicated in Capecitabine Pharmacodynamics on the Effectiveness of Adjuvant Therapy in Colorectal Cancer.

International journal of molecular sciences - 20 Dec 2023

Cura Yasmin, Sánchez-Martín Almudena, Márquez-Pete Noelia, González-Flores Encarnación, Martínez-Martínez Fernando, Pérez-Ramírez Cristina, Jiménez-Morales Alberto

Abstract excerpt

Colorectal cancer (CRC) is a highly prevalent form of neoplasm worldwide. Capecitabine, an oral antimetabolite, is widely used for CRC treatment; however, there exists substantial variation in individual therapy response. This may be due to genetic variations in genes involved in capecitabine pharmacodynamics (PD). In this study, we investigated the role of single-nucleotide polymorphisms (SNPs) related to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38203276
DOI: 10.3390/ijms25010104
PMCID: PMC10778960

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