Article
Development of a tool for predicting HNF1B mutations in children and young adults with congenital anomalies of the kidneys and urinary tract.
Pediatric nephrology (Berlin, Germany) - 1 Jun 2024
Kołbuc Marcin, Kołek Mateusz F, Motyka Rafał, Bieniaś Beata, Habbig Sandra, Burgmaier Kathrin, Prikhodina Larisa, Papizh Svetlana, Tasic Velibor, Okorn Christine, Szczepańska Maria, Kiliś-Pstrusińska Katarzyna, Wasilewska Anna, Adamczyk Piotr, Tkaczyk Marcin, Pańczyk-Tomaszewska Małgorzata, Miklaszewska Monika, Pawlaczyk Krzysztof, Bukowska-Olech Ewelina, Jamsheer Aleksander, Jankauskiene Augustina, König Jens, Cheong Hae Il, Ahn Yo Han, Kaspar Sophie, Sikora Przemysław, Beck Bodo B, Zaniew Marcin
Abstract excerpt
BACKGROUND: We aimed to develop a tool for predicting HNF1B mutations in children with congenital abnormalities of the kidneys and urinary tract (CAKUT). METHODS: The clinical and laboratory data from 234 children and young adults with known HNF1B mutation status were collected and analyzed retrospectively. All subjects were randomly divided into a training (70%) and a validation set (30%). A random forest model...
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