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Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome

3 Jan 2024

Abstract excerpt

ABSTRACT: Patients with Sézary syndrome (SS), a leukemic variant of cutaneous T-cell lymphoma (CTCL), are prone to Staphylococcus aureus infections and have a poor prognosis due to treatment resistance. Here, we report that S aureus and staphylococcal enterotoxins (SE) induce drug resistance in malignant T cells against therapeutics commonly used in CTCL. Supernatant from patient-derived, SE-producing S aureus...

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Identifiers

PMID: 38170178
DOI: 10.1182/blood.2023021671

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