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Article

Inescapable foot shock induces a PTSD-like phenotype and negatively impacts adult murine bone.

Disease models & mechanisms - 1 Jan 2024

Sidles Sara J, Kelly Ryan R, Kelly Kirsten D, Hathaway-Schrader Jessica D, Khoo Stephanie K, Jones Jeffrey A, Cray James J, LaRue Amanda C

Abstract excerpt

Post-traumatic stress disorder (PTSD) is associated with osteopenia, osteoporosis and increased fracture risk in the clinical population. Yet, the development of preclinical models to study PTSD-induced bone loss remains limited. In this study, we present a previously unreported model of PTSD in adult female C57BL/6 mice, by employing inescapable foot shock and social isolation, that demonstrates high face and...

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Identifiers

PMID: 38131122
DOI: 10.1242/dmm.050044
PMCID: PMC10820809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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