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Sanger and Next-Generation Sequencing of AAT.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2024

Barzon Valentina, Ferrarotti Ilaria, Ottaviani Stefania

Abstract excerpt

Sequencing of DNA is normally the final procedure carried out to determine the actual pathogenic variants when the techniques used for genotyping are unable to provide complete identification of both AAT alleles. Gene sequencing of complete SERPINA1 gene by using the Sanger method or next-generation sequencing (NGS) is crucial to enable correct diagnosis in patients with alpha1-antitrypsin deficiency caused by...

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Identifiers

PMID: 38108967
DOI: 10.1007/978-1-0716-3605-3_6

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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