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Oral Metformin Inhibits Choroidal Neovascularization by Modulating the Gut-Retina Axis

18 Dec 2023

Abstract excerpt

Purpose: Emerging data indicate that metformin may prevent the development of age-related macular degeneration (AMD). Whereas the underlying mechanisms of metformin's anti-aging properties remain undetermined, one proposed avenue is the gut microbiome. Using the laser-induced choroidal neovascularization (CNV) model, we investigate the effects of oral metformin on CNV, retinal pigment epithelium (RPE)/choroid...

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PMID: 38108689
DOI: 10.1167/iovs.64.15.21

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