Article
A Rare Case of COVID-19 Related Acute Necrotizing Encephalopathy With the RANBP2 Mutation in a Pediatric Patient.
The Pediatric infectious disease journal - 1 Mar 2024
Christou Evangelos, Kotsia Alkisti, Tziouvas Konstantinos, Filias Panagiotis, Patsoura Aristoula
Abstract excerpt
Acute necrotizing encephalopathy (ANE) is a rare childhood neurological disorder. The familiar type of ANE (ANE1) is associated with a mutation in the RANBP2 gene. Both SARS-CoV-2 and RANBP2 mutations are responsible for the manifestation of a hyper-inflammatory response that invades the central nervous system and plays a key role in the rapid progression of encephalopathy.
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