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Beyond ENO1, emerging roles and targeting strategies of other enolases in cancers

10 Nov 2023

Abstract excerpt

Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes ENO1, ENO2, and ENO3. The altered expression of enolases is a common occurrence in various types of cancer. Although most published studies on enolases have predominantly...

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PMID: 38075246
DOI: 10.1016/j.omto.2023.100750

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