Article
Morphologic, phenotypic, and genotypic similarities between primary tumors and corresponding 3D cell cultures grown in a repeatable system-preliminary results.
BMC veterinary research - 9 Dec 2023
Muscatello Luisa Vera, Frabetti Stella, Avallone Giancarlo, Gobbo Francesca, Pasquini Arianna, D'Annunzio Giulia, Pisoni Luciano, Marconato Laura, Terragni Rossella, De Biase Dario, Candini Olivia, Sarli Giuseppe
Abstract excerpt
BACKGROUND: Three-dimensional (3D) cell cultures are the new frontier for reproducing the tumor micro-environment in vitro. The aims of the study were (1) to establish primary 3D cell cultures from canine spontaneous neoplasms and (2) to demonstrate the morphological, phenotypic and genotypic similarities between the primary canine neoplasms and the corresponding 3D cultures, through the expression of tumor...
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