Article
cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype.
Animal genetics - 1 Aug 2008
Rao N A S, van Wolferen M E, van den Ham R, van Leenen D, Groot Koerkamp M J A, Holstege F C P, Mol J A
Abstract excerpt
Mammary cancer is the most common type of cancer in female dogs with a lifetime risk of over 24% when dogs are not spayed. The elucidation of the complete canine genome opens new areas for development of cancer therapies. These should be tested first by in vitro models such as cell lines. However, to date, no canine mammary cell lines have been characterized by expression profiling. In this study, canine mammary...
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