Article
Whole genome sequencing in families with oligodontia.
Oral diseases - 1 Sept 2024
Mitscherling Janna, Sczakiel Henrike L, Kiskemper-Nestorjuk Olga, Winterhalter Sibylle, Mundlos Stefan, Bartzela Theodosia, Mensah Martin A
Abstract excerpt
BACKGROUND/OBJECTIVES: Tooth agenesis (TA) is among the most common malformations in humans. Although several causative mutations have been described, the genetic cause often remains elusive. Here, we test whether whole genome sequencing (WGS) could bridge this diagnostic gap. METHODS: In four families with TA, we assessed the dental phenotype using the Tooth Agenesis Code after intraoral examination and...
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