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Article

Enhancer-mediated FOXO3 expression promotes MSC adipogenic differentiation by activating autophagy

2 Dec 2023

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) are pluripotent stem cells capable of differentiating into osteocytes, adipocytes and chondrocytes. However, in osteoporosis, the balance of differentiation is tipped toward adipogenesis and the key mechanism is controversial. Researches have shown that, as upstream regulatory elements of gene expression, enhancers ar involved in the expression of identity genes. In this...

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PMID: 38043828
DOI: 10.1016/j.bbadis.2023.166975

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