Article
Mutation of mltG increases peptidoglycan fragment release, cell size, and antibiotic susceptibility in Neisseria gonorrhoeae.
Journal of bacteriology - 19 Dec 2023
Harris-Jones Tiffany N, Pérez Medina Krizia M, Hackett Kathleen T, Schave Melanie A, Klimowicz Amy K, Schaub Ryan E, Dillard Joseph P
Abstract excerpt
IMPORTANCE: Neisseria gonorrhoeae is unusual in that the bacteria release larger amounts of cell wall material as they grow as compared to related bacteria, and the released cell wall fragments induce inflammation that leads to tissue damage in infected people. The study of MltG revealed the importance of this enzyme for controlling cell wall growth, cell wall fragment production, and bacterial cell size and...
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