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Article

Salivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer

30 Nov 2023

Abstract excerpt

BACKGROUND: Oral squamous cell carcinoma (SCC) is associated with oral microbial dysbiosis. In this unique study, we compared pre- to post-treatment salivary microbiome in patients with SCC by 16S rRNA gene sequencing and examined how microbiome changes correlated with the expression of an anti-microbial protein. RESULTS: Treatment of SCC was associated with a reduction in overall bacterial richness and...

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PMID: 38037123
DOI: 10.1186/s40168-023-01677-w

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