Article
A phenome-wide scan reveals convergence of common and rare variant associations.
Genome medicine - 28 Nov 2023
Zhou Dan, Zhou Yuan, Xu Yue, Meng Ran, Gamazon Eric R
Abstract excerpt
BACKGROUND: Common and rare variants contribute to the etiology of complex traits. However, the extent to which the phenotypic effects of common and rare variants involve shared molecular mediators remains poorly understood. The question is essential to the basic and translational goals of the science of genomics, with critical basic-science, methodological, and clinical consequences. METHODS: Leveraging the...
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