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CYP2D6 genotyping and the clinical impact on outcomes in breast cancer tamoxifen-treated patients.

Personalized medicine - 1 Nov 2023

Ramírez Gabriel, Vital Marcelo, Vergara Carolina, Carusso Florencia, Neffa Florencia, Valle Adriana Della, Esperón Patricia

Abstract excerpt

Aims: To report the distribution of allele frequencies of CYP2D6 gene and to evaluate their influence on the clinical outcomes of a group of breast cancer patients receiving adjuvant tamoxifen treatment from Uruguay. Patients & methods: 199 samples were genotyped through real-time polymerase chain reaction assays. Metabolization profiles were inferred from the genotypes. Correlations were evaluated using...

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PMID: 37947089
DOI: 10.2217/pme-2023-0063

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