Article
A systematic review regarding the prevalence of malignancy in patients with the hyper-IgE syndrome.
Clinical and experimental medicine - 1 Dec 2023
Mohammadi Tayebeh, Azizi Gholamreza, Rafiemanesh Hosein, Farahani Pouria, Nirouei Matineh, Tavakol Marzieh
Abstract excerpt
The hyper-immunoglobulin E syndrome (HIES) is a primary immunodeficiency disease originally described as Job syndrome. The fundamental causative variant of the HIES is an autosomal dominant mutation in the signal transducer and activator of transcription 3 (STAT3) gene. It is characterized by recurrent staphylococcal cold skin abscess, sinopulmonary infection, eczema, head and face anomalies, frequent bone...
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