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Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma

31 Oct 2023

Abstract excerpt

The genomic instability (GI) /homologous recombination deficiency (HRD) score, calculated as the sum of the events of loss of heterozygosity (LOH), large-scale state transition (LST) and telomere allele imbalance (TAI), is used to guide the choice of treatment in several cancers, but its relationship with genomic features, clinicopathological characteristics and prognosis in lung cancer is poorly understood,...

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PMID: 37907595
DOI: 10.1038/s41698-023-00465-x

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