Article
Association of variants in the ABCB1, CYP2C19 and CYP2C9 genes for Juvenile Myoclonic Epilepsy.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Apr 2024
Jara-Prado Aurelio, Guerrero-Camacho Jorge Luis, Ángeles-López Quetzalli Denisse, Ochoa-Morales Adriana, Dávila-Ortiz de Montellano David José, Ramírez-García Miguel Ángel, Breda-Yepes Michelle, Durón Reyna M, Delgado-Escueta Antonio V, Barrios-González Diego A, Martínez-Juárez Iris E
Abstract excerpt
Juvenile myoclonic epilepsy (JME) is the most common of the generalized genetic epilepsies, with multiple causal and susceptibility genes; however, its etiopathogenesis is mainly unknown. The toxic effects caused by xenobiotics in cells occur during their metabolic transformation, mainly by enzymes belonging to cytochrome P450. The elimination of these compounds by transporters of the ABC type protects the...
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