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Article

Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins.

eLife - 18 Oct 2023

Zhang Yingnan, Zhang Kelly, Prakosa Adityo, James Cynthia, Zimmerman Stefan L, Carrick Richard, Sung Eric, Gasperetti Alessio, Tichnell Crystal, Murray Brittney, Calkins Hugh, Trayanova Natalia A

Abstract excerpt

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease that leads to ventricular tachycardia (VT), a life-threatening heart rhythm disorder. Treating ARVC remains challenging due to the complex underlying arrhythmogenic mechanisms, which involve structural and electrophysiological (EP) remodeling. Here, we developed a novel genotype-specific heart digital twin (Geno-DT) approach to...

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Share to Arrhythmias, Cardiac
Share to Arrhythmogenic Right Ventricular Dysplasia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiac Arrhythmias and Treatments

Share to Cardiac electrophysiology and arrhythmias

Share to Cardiovascular Effects of Exercise

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Source

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Identifiers

PMID: 37851708
DOI: 10.7554/eLife.88865
PMCID: PMC10584370

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