Article
Summary-data based Mendelian randomization identifies gene expression regulatory polymorphisms associated with bovine paratuberculosis by modulation of the nuclear factor Kappa β (NF-κß)-mediated inflammatory response.
BMC genomics - 11 Oct 2023
Badia-Bringué Gerard, Canive Maria, Fernandez-Jimenez Nora, Lavín José Luis, Casais Rosa, Blanco-Vázquez Cristina, Vázquez Patricia, Fernández Almudena, Bilbao Jose Ramón, Garrido Joseba M, Juste Ramón A, González-Recio Oscar, Alonso-Hearn Marta
Abstract excerpt
Genome-wide association studies (GWAS) have identified host genetic variants associated with paratuberculosis (PTB) susceptibility. Most of the GWAS-identified SNPs are in non-coding regions. Connecting these non-coding variants and downstream affected genes is a challenge and, up to date, only a few functional mutations or expression quantitative loci (cis-eQTLs) associated with PTB susceptibility have been...
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