Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

Abstract excerpt

ABSTRACT Staphylococcus aureus ( S. aureus ) represents a major clinical challenge due to its explicit capacity to select mutations that increase antibiotic resistance and immune evasion. However, the molecular mechanisms are poorly defined, especially for adaptive immunity. Cancer immunotherapy targeting programmed cell death protein 1 (PD-1) enhances T-cell activity and is emerging for the treatment of certain...

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