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A New Paradigm of the Origins of Circulating DNA in Patients with Cancer

5 Oct 2023

Abstract excerpt

SUMMARY: By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying...

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PMID: 37794839
DOI: 10.1158/2159-8290.cd-23-0824

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